Straight from the back of the first cover:

--22 years ago, a cataclysmic earthquake destroyed the Kanagawa region of Japan and threw the country into chaos. The damaged region was abandoned and labeled the Muraji Special Economic District, more commonly known as the Lost Ground. After the eartquake, the Lost Ground became home to a rising number of Alter Users, those with the psychic ability to change the matter and create Alters with unique powers.--



The main character of this anime is Kazuma, a Native Alter. He hates the people of the city with a passion, along with HOLD and HOLY. HOLD is the army of the city, and HOLY is made completely of alter users whom have sworn their allegiance to HOLY. They are there to take care of the Native Alters whom they say are out of control.

Ryuho, a member of HOLY, has hated Kazuma ever since he met him, and Kazume feels the same way about him.